Oxenford will become the fifth Australian and 18th in world cricket to officiate 50 Tests when England and India's fourth Test begins on Thursday.
A former Queensland first-class player and foundation club-captain of Premier Club the Gold Coast Dolphins, Oxenford has also stood in 88 One-Day and 20 T20 Internationals.
He made his international umpiring debut in a T20 International between Australia and South Africa at the Gabba in 2006 before standing in his first Test in 2010 between Sri Lanka and the West Indies.
Queensland Cricket Chief Executive Officer Max Walters paid tribute to Oxenford's achievement and his contribution to cricket in Queensland and Australia.
"Bruce has enjoyed a great career as an international umpire and we congratulate him for reaching this milestone.
"Having played a major role in developing cricket on the Gold Coast and reaching the game's pinnacle as a domestic player by representing his state, it is with great pride that we have seen him become one of the game's best officiators.
"Queensland Cricket would like to thank and congratulate him on his 50th Test and everything he has contributed to the game."
The fourth Test between England and India begins on Thursday evening Australian time.