The Queensland 2nd XI won inside three days to stay in touch with the top two of the competition.
Paceman Mark Steketee's belligerent second innings knock of 57 not out ensured the home side finished with a second innings total of 295, setting the visitors a healthy target to chase.
Bulls quicks Pete George and Luke Feldman were up for the challenge, using the Dukes ball to good effect as they claimed 4-52 and 3-18 respectively as SA was dismissed for 179.
Cameron Gannon showed his return from a major shoulder operation last year was complete, adding 2-12 to his first innings haul of 6-50.
Earlier, Bulls squad batsman Bryce Street produced a composed knock of 69 to top score for the QAS in their second innings.
Queensland play their final Futures League match at Allan Border Field from 25 February.
QAS 219 (C Hemphrey 111, LD Pfeffer 36, CJ Gannon 27; N Winter 8/58) and 295 (BE Street 69, MT Steketee 57*, SJ Truloff 43, C Hemphrey 31; C Valente 3/70, N Winter 3/74, D Drew 2/52) def South Australia 234 (TD Andrews 59*, C Valente 48, CJ McInerney 36; CJ Gannon 6/50, M Kuhnemann 2/19, MT Steketee 2/78) and 173 (N Winter 59, C Valente 48; PR George 4/52, LW Feldman 3/18, CJ Gannon 2/12)